Although bacteria have been mainly recognized as disease causing agents since the discovery of their identity, there are abundant scientific evidences that bacterial pathogenicity is not the major biological function of bacteria. Microbiologists have traditionally focused on disease studies rather than on the diverse beneficial functions of bacteria. Recently, cancer/micro-biologists serendipitously discovered an important beneficial function of bacteria as anti-cancer agents. This is consistent with the idea that bacteria were originally created to perform beneficial functions. In order to maximize the medical benefits of bacterial oncolysis, genetic attenuation of bacteria (reduction of pathogenicity) can be used to help reduce the pathogenecity of bacteria while not diminishing oncolytic activity. The oncolytic role of bacteria within the creation model will be examined in this paper.