The Principia is the founding document of physics and astronomy as we know them, and it played a key role in the scientific revolution four centuries ago. For two centuries afterward, mathematicians worked out the details of Newtonian mechanics, which led to determinism. The rise of modern physics in the early twentieth century undermined determinism, leading to indeterminism. In the seventeenth century, the so-called Enlightenment hijacked science, robbing it of its foundation in a worldview that had biblical elements, replacing it with a foundation of humanism. This has led to a growing hostility toward any concern of theism in scientific endeavors. The trends undermine the worldview that created science in the first place. Consequently, the future of science may be in question.