We have been created fearfully and wonderfully by our Creator God, and the human body showcases God's intricate design. Design features are evident in the structures and functions of each of the body systems. In this paper, I present a design approach to the study of human anatomy and physiology from a biblical worldview. I establish a theology of the body as a foundation for the study of human structure and function. I then discuss key repeating themes in the human body systems as evidence for design and offer suggestions for biblical integration in the study of these themes. I also highlight the concept of overdesign in the human body as evidence for a Great Designer. I conclude the paper with a discussion of ways that a design approach to the study of anatomy and physiology could inspire praise, promote deeper reflection on God and His creation, and encourage a holistic view of stewardship of the body.