The central dogma of neo-Darwinism is: Mutations provide variety that is selected by natural selection. Mutations and natural selection are ultimately the only driving force of evolution, but they are effective only if one or more mutations prove beneficial to an organism in a given environment. In evolution, natural selection can do nothing without mutations. Since macromutations are virtually all near-neutral or harmful, micromutations are the only means by which new species could possibly evolve. The probability that micromutations will lead to new species is so low as to be close to zero. One reason is the net deterioration of the genome that occurs as a result of mutations, especially near-neutral mutations, which selection and medical advances cannot counteract. Furthermore, nonrandom "mutations" are controlled by in-built cellular processes and, therefore, cannot be a cause of evolution. A large number of studies clearly show that the central dogma has failed, and this devastates the credibility of neo-Darwinism. Furthermore, the increasing knowledge of the immense complexity of life at the molecular level has buttressed both the Creation and Intelligent Design movements.