Various theories of the evolution of the human hand are analyzed, revealing much speculation, but little evidence, for the evolutionary origin of this complex and highly designed system. The hand would require the simultaneous evolution of large set of intricate and matched structures, including bones, muscles, blood vessels, ligaments, tendons, skin, and nerves. In addition, the brain must have evolved systems enabling the coordinated function of the hand as an integrated unit. The result is an anatomical system that is one of the most critical parts of what makes us human. In comparison to the primate hand, there are several significant differences that indicate the uniqueness of the human hand. Also, the enormous versatility of the hand, such as ability to do tasks requiring fine motor coordination as well as brute strength, are discussed.