This article reviews five decades of work published in the CRSQ concerning the application of chemistry and biochemistry to chemical evolution, also known as abiogenesis. The author, Theodore J. Siek, organizes the review not chronologically, but rather according to the hypothesized steps of chemical evolution, starting from the formation of amino acids in a primitive atmosphere to the development of the first cells. A central theme throughout the examined articles is the challenges and purported impossibilities of chemical evolution as viewed through a creationist lens, with significant attention given to issues like the lack of evidence for a primordial oxygen-free atmosphere, thermodynamic barriers, the chirality problem of amino acids, and the complexity of forming essential biomolecules and a self-replicating cell by natural processes alone.