Characterizing and understanding original tissue fossils holds great interest because of what these fossils imply about the incongruous timelines that help define biblical creation versus evolution. General expectations suggest, and repeatable lab experiments demonstrate, that biomaterials original to fossilized organisms have a finite shelf life. Tissues in fossils confront evolutionary time. This article reviews generations of research that have exposed and explored original biomaterial fossils, establishing beyond reasonable doubt the reality of endogenous fossil tissues as a genuine feature of Earth layers. It also surveys original biomaterial fossils in geological context and updates both the secular and creation-based research status of this science. We conclude that original biomaterials found throughout the fossil record confirm the biblical timeline of Creation-Flood geology.