Open, unanswered questions in the field of origin of life (OoL) describe the vast gaps in explaining the supposed historical, continuous, and naturalistic path from lifeless chemicals to cellular life that utilizes genetics and metabolism. At three recent international conferences, participants clarified dozens of open questions on the origin of life (OQ/OoL) and discussed possible scientific and philosophical resolutions. This paper examines a few important OQ/OoL from the perspective that a naturalistic OoL scenario contradicts the revelation of creation in Scripture and that scientific research is bringing into focus how difficult it will be to resolve these OQ/OoL, rather than converging toward explanations for a naturalistic, historical explanation of the OoL.