The Genesis account states that God created all living things according to their kinds. Cattle, bison, and buffalo are identified as being derived from a single created kind (i.e., they belong to a monobaramin). Karyotype variability is examined within this monobaramin. I conclude that chromosomal rearrangements, particularly centric fusions, have played an important role in developing the chromosomal patterns that are seen in these animals today. Furthermore, it appears that these rearrangements are dependent on numerous mechanisms (to repair breaks, deactivate a centromere, and restructure heterochromatin) that allow for such changes while maintaining the viability of the animal. Since different fusions have become fixed in different populations, it is proposed that these changes are likely beneficial. The precision necessary to fuse two chromosomes, inactivate one centromere, and adjust the amount of heterochromatin suggests that the chromosomal translocation mechanisms were designed by God to provide for His creatures in this present fallen world.