The case for over-design is reviewed focusing on documented cases of normal persons that have exceptional abilities. Over-design refers to mental skills that exist at levels well-beyond that required for survival. Typical abilities and skills achieved by the human brain, such as in music, math, memory, and design, are also used as examples to illustrate the concept of over-design. Several case histories of exceptional abilities were reviewed to illustrate extreme cases of mental over-design. These cases provide strong support for a level of intelligent design that cannot be explained by Darwinism. A literature review concludes these exceptional skills remain unexplained in spite of numerous scientific studies that have explored this topic. Among those persons convinced that over-design requires an intelligent creator is the co-founder of the modern Neo-Darwinism theory of evolution, Alfred Russel Wallace.