Man’s vital organs are preeminently designed to facilitate his existence in the upright position. Because man’s bipedal locomotion is unique, he is not a remodeled ape or monkey. A conjectural interpretation is offered that the quadruped position of lower animals and the crawling position of reptiles resulted from the Edenic curse. Man’s unquenchable instinct to worship is discussed as the important spiritual counterpart to his upright position. Worship implies that physical act, which is unique in man, of bowing down from the upright position.