Mutations are normally classified according to their proximal effect on an organism's fitness, whether beneficial, deleterious, or neutral. While this is a very useful first-pass categorization of mutations, the realization that mutations are not always haphazard, but in fact may be part of a regulated design, means that creationists should be looking for a deeper classification of mutations based on whether or not they conform to their organism's design. Design-consistent mutations are those which occur within the pattern expected by the genome's architecture, and design-inconsistent mutations are those which occur outside of the genome's architecture. Features such as metabolic consistency, mutational mechanism, mutation rate, reversibility, and preservation of genome semantics can be used by biologists to assess whether or not a mutation is design-consistent or design-inconsistent.