This study is an attempt to understand from a cytogenetic perspective the physical aspects of the means God might have used to accomplish the miracle of the virgin conception of Jesus Christ. It distinguishes three separate but related factors pertinent to the physical aspects of this miracle: (1) Man's fall and inheritance of original sin, (2) the second-law-of-thermodynamics curse of death and (3) the precise gametogenic definition of the seed of the woman. Although this study postulates a physical component to our sin nature and its inheritance, it does not propose, or even imply, that our sin nature is purely genetic or merely physical. From these considerations, a possible cytogenetic mechanism is described whereby the physical aspects of the virgin birth of Jesus Christ could have contributed to His being both fully God and fully man, sinless, yet able to die as the perfect Sacrifice to save us from our sins.