Genesis, chapter one, is discussed in terms of whether half lives could have been smaller early in creation week. Radioactive equilibrium of uranium is discussed in terms of such a scenario, along with U-235 and Pu-244 abundances. The discussion is related to evolutionary thoughts about element production in stars. I discuss the possibility of variation of coupling constants and particle masses within modern string theory. Finally, a concrete, numerical approach is given for the possible variation of the Fermi constant over the history of the earth.