Proper protein folding requires specific "chaperones" and other molecular machinery called "folding factors." Both the genomic code and the folding machinery are required in order to produce a functional protein. The cell also has an elaborate quality control system to ensure that the cellular parts are manufactured to the required specifications. Recent research has added new levels of complexity to our current level of understanding of cell biology quality control. One important role of this newly discovered system is the removal and recycling of improperly folded proteins caused by any number of factors including mutations. Mutations are assumed by neo-Darwinists to be the ultimate source of all new genetic information. In order to produce a new protein by mutations, however, both appropriate folding and quality control systems also must adapt. Without them, a mutant is useless, even if it produces a selective advantage. Quality control results in many, if not most, mutated proteins being repaired or cut up and recycled, even if they are beneficial to the organism. This detail manifests irreducible complexity that favors intelligent design.