By reference to beans, roses and corn, variation is shown to be limited and not unlimited as Darwin thought. Mutations are generally harmful. Even assuming a 1% advantage, which no mutation reported has actually shown, rate of accumulation of mutations in a species is so slow that it would take about 1,000,000 years for a species population to become uniform for one mutation. This makes them ineffective even in microevolution as means of accumulating the constant features distinguishing species. The giraffe is used to illustrate this fact. Also biological species show remarkable variation in chromosome number and form. Translocation and inversions occur rarely and spontaneously in species populations. Most translocations in the fruit fly, Drosophila, are either inviable when homozygous or cause a reduction in fertility in one or both of the sexes. In plants, homozygous translocation are usually normal in fertility and vigor. However, none of them are more vigorous than the normal or standard type. Accordingly there is simply no way for them to become established as homozygotes in all the individuals of the population. Experimentally produced polyploids are variable in chromosome number due to quadrivalent formation and so their offspring have a variable chromosome number. Also they are reduced in fertility, so could not become established in nature, since natural selection would operate against them. Some idea of the complexity of the DNA-RNA system is given. This remarkable interlocking system could not be the result of chance variation. Also reference to work with bacteriophage and tobacco mosaic virus shows that these organisms will not stand the slightest change in the nucleotide bases or their order in the very long and complex DNA molecule. Only the genius of a remarkably intelligent Being we worship as God could have designed such an efficient yet intricate system.