The cause of Darwin’s long-term health problems has been the subject of several books and scores of academic publications. Among the many theories include Darwin’s acknowledgment that his goal was to "murder God" by developing a creation theory that negated the most common reason given for belief in Him, namely the beauty and complexity of the physical world. This theory Darwin developed to that end was natural selection, although Darwin himself had doubts about the ability of the mechanism he proposed to account for all of creation. As will be reviewed, a good case has been made by several Darwin scholars for the murder hypothesis causing guilt that accounts for many, if not most, of Darwin’s psychological problems (which, in turn, had a large influence on causing his many physical maladies). The "cold-water episode" recounted in this paper supports this conclusion.