The physical constants of the Universe are fine-tuned to support life, and a design inference logically follows. One can avoid this inference under the assumption that cosmic inflation has produced an inflationary multiverse comprising many universes, a few of which possess the conditions requisite for life. Thus this article first reviews the presuppositional bankruptcy of naturalism and then examines the scientific merits of both inflation and its consequent multiverse, as well as of the hypothesis that a quantum fluctuation produced the Universe. We find that, besides the a priori failure of naturalism in general, the hypothesized scenario is in tension with fundamental principles of science and functions rather as a modern origins myth.