All known organisms, except RNA viruses, contain a DNA genome. The percentage of the part of the genome encoding genes, including protein-coding and non-protein coding genes, differ greatly among organisms. Regardless, all genes are encoded in DNA or RNA. In all cells, DNA and RNA are generated using DNA or RNA templates. This article argues, based on theoretical considerations, as well as bottom-up and top-down experimental data, that it is practically impossible to generate the first DNA (or RNA) template abiotically.