McCann (1991) has developed a model for embryogenesis and other aspects of differentiation that subordinates developmental genetics to a quality he defines as "cellular intelligence." We debate this paradigm in light of currently understood genetic principles and functions, information theory, and the Creationist concept of origins. We contend that "cellular intelligence" is a non-entity, that cells are neither creative nor "intelligent" entities, but are informed entities. The dichotomy between intelligence and information is defined in terms of organizational hierarchy and antecedents. Since information is not spontaneously generated, the information guiding development and differentiation is hereditary, being archetypical in origin and genomic in location. The ultimate source of that genetic information is Creative intelligence. Cytodifferentiation is primarily a function of gene regulation and information transduction, according to a variety of tangible constitutive and inducible mechanisms and cellular components. The latter include homeotic genes, gene promoter, repressor, and enhancer elements, receptors, protein kinases, the cytoskeleton, and the dynamic three-dimensional tertiary structure of DNA itself. The limitations McCann would place on "gene action" respective of phenotypic variation and development are untenable.