An evaluation of DNA/RNA mutations indicates that they cannot provide significant new levels of information. Instead, mutations will produce degradation of the information in the genome. This is the opposite of the predictions of the neoDarwinian origins model. Such genome degradation is counteracted by natural selection that helps maintain the status quo. Degradation results for many reasons, two of which are reviewed here: 1) there is a tendency for mutations to produce a highly disproportionate number of certain nucleotide bases such as thymine and 2) many mutations occur in only a relatively few places within the gene called "hot spots," and rarely occur in others, known as "cold spots." An extensive review of the literature fails to reveal a single clear example of a beneficial information-gaining mutation. Conversely, thousands of deleterious mutations exist, supporting the hypothesis that very few mutations are beneficial. These findings support a creation origins model.