This review of attempts to postulate evolutionary theories for the origin and development of cartilage and the cells that produce cartilage. The review found a complete lack of evidence for both the origin and development of cartilage. Even plausible "just-so" stories have not been attempted by evolutionists. For mammals, especially primates, life would not be possible without cartilage. This is yet another example of a body structure whose evolutionary origin completely baffles Darwinists. They recognize that mammalian life could not survive without cartilage and yet cannot explain how cartilage evolved to be part of the mammal-body design. Cartilage is, therefore, part of the irreducibly complex design of mammals that meets Darwin's bold 1859 challenge that "If it could be demonstrated that any complex organ existed, which could not possibly have been formed by numerous, successive, slight modifications, my theory would absolutely break down" (Darwin 1859, 189). Although Darwin wrote that he did not know of any such contrary example, cartilage is one of many excellent Darwin-defying candidates.